Folate -30 Capsules 1,000 mcg each Metafolin L-5-MTHF

 

Scientific Name: Metafolin L-5-methyltetrahydrofolate (L-5-MTHF

Origin: USA

*Please do not use folate with Calcium supplements 

• Our Folate provides 1,000 mcg per capsule of Metafolin L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate.
• Optimal Wellness: Folate is essential in fetal development and plays an important role in the maintenance of muscle tone in the G.I. tract, the functioning of the nervous system, and the integrity of skin, hair, and the liver.*
• Cellular Health: Adequate folate intake may provide significant cardiovascular, cellular and neural support.*

Fertility 

Taking folate can not only improve your chances of conceiving, but it also reduces the risk of serious birth defects that can occur in the first month of pregnancy.

First things first: What is folate?

Folate (also known as vitamin B9) is a nutrient that plays an important role in red blood cell formation and DNA synthesis. Because of this, it’s especially crucial during early pregnancy.

During pregnancy, folate supports a baby’s healthy neural tube development and is very important in the early weeks.

Recommended folate intake increases during pregnancy to fuel rapid growth and help prevent neural tube defects  like spina bifida, and other midline birth defects.

 This is why it’s important to have enough folate before you even get pregnant and during the first trimester—so that during those first few weeks (when you might not even know you’re pregnant) you’re still supporting these key development milestones.

 There is also evidence that folate promoted optimal fertilization and implantation and as such, anyone planning to get pregnant should take folate for at least three months prior to conception and continue through the postpartum period.

 Folate- rich foods include spinach, liver, asparagus, and brussels sprouts. However, if you are unable to  get a recommended 6-8 servings of green vegetables a day,  Supplementation is often a great way to make sure you’re getting enough folate.

After the loss of my baby to Spina BIFIDA (a neural tube birth defect) several years ago- I became aware of the importance of supplementing with folate

Listen up ladies, if there's any chance that you CAN get pregnant, it is super duper important that you supplement with folate even BEFORE you get pregnant to prevent neural tube defects in your baby.

However you need to understand the differences between folate and folic acid as they are often used incorrectly and interchangeably.

In the past three October's we have tackled this conversation whilst educating on Spina BIFIDA.

Folate and Folic Acid are two distinct compounds with different functions in the body.

Folate is naturally occurring while Folic acid is the synthetic form of folate.

Folate is the form of vitamin B9 that you find in foods like leaty green veggies, liver, nuts and seeds etc.

It is an essential nutrient, critical for the growth of healthy cells and DNA creation thus extremely important to get before and during pregnancy.

Major difference:

Folate converts to active form 5-MTHF that your body utilizes best.

Folic has a hard time converting to 5-MTHF in the body.

The body can only process so much folic acid because It is difficult to metabolize.

The natural form of B9, folate, is much more easily processed and utilized.

Adequate ingestion of folate is of primary importance for women TTC especially very early in pregnancy. It's been associated with decreased risk of Neural Tube Defects, congenital heart defects, and oral clefts, i.e. cleft palate.

 

ADHD (Attention-Deficit/Hyperactivity Disorder)

Folate, particularly in its active form, L-methylfolate, has gained attention for its potential benefits in managing symptoms of ADHD (Attention-Deficit/Hyperactivity Disorder). Here’s how folate may be relevant for individuals with ADHD:

1. Folate’s Role in Brain Health

• Folate, or vitamin B9, plays a crucial role in brain function and development. It is involved in the production of neurotransmitters, including dopamine, norepinephrine, and serotonin, which are critical for mood regulation, attention, and impulse control—areas often impaired in ADHD.

• Low folate levels have been associated with cognitive and behavioral issues, making proper folate levels important for mental health and cognitive performance.

2. Folate and Methylation

• Folate is involved in a process called methylation, which is important for producing neurotransmitters and maintaining overall brain health. Methylation also influences gene expression and the repair of DNA, both of which are essential for optimal brain function.

• Some individuals, especially those with MTHFR gene mutations, have difficulty converting folic acid (the synthetic form of folate) into its active form, L-methylfolate. This can lead to folate deficiency and suboptimal methylation, potentially contributing to ADHD symptoms.

3. L-Methylfolate for ADHD

• L-methylfolate is the bioactive form of folate that can be readily used by the brain, even in individuals with MTHFR mutations. Supplementing with L-methylfolate ensures that the body has enough of this crucial nutrient to support neurotransmitter production and cognitive function.

• Some studies suggest that addressing methylation issues and folate deficiencies in individuals with ADHD can help improve symptoms such as focus, attention, and mood regulation. However, research specifically linking L-methylfolate supplementation to improvements in ADHD symptoms is still limited.

4. Comorbidity with Mood Disorders

• Children and adults with ADHD often experience comorbid conditions like depression or anxiety. L-methylfolate has been studied for its potential to alleviate depression by supporting serotonin production, which could benefit those with both ADHD and mood disorders.

• Folate’s involvement in mood regulation could indirectly help manage some of the emotional dysregulation seen in ADHD patients.

5. Folate and Medications

• Folate may also enhance the effectiveness of certain medications used to treat ADHD. For example, it is sometimes recommended alongside stimulant medications or antidepressants to support cognitive and emotional well-being.

6. Research on Folate and ADHD

• Some studies indicate that individuals with ADHD, particularly those with genetic mutations affecting folate metabolism, may benefit from L-methylfolate supplementation.

• A 2018 study found that folate deficiency in pregnant women was associated with an increased risk of ADHD in their children. This points to the importance of adequate folate levels during development for long-term brain health.

Conclusion

While more research is needed to fully understand the role of folate in ADHD, there is evidence suggesting that adequate folate levels, particularly in the form of L-methylfolate, may support brain function and neurotransmitter production, potentially helping to manage symptoms of ADHD. Individuals with ADHD, especially those with genetic variations affecting folate metabolism, may benefit from supplementing with L-methylfolate, but it’s crucial to consult a healthcare provider before starting any supplementation regimen.

Autism

Folate, especially in its bioactive form L-methylfolate, plays an important role in brain development and function, and has been explored for its potential benefits in individuals with autism spectrum disorder (ASD). Here’s how folate may be relevant for autism:

1. Folate and Brain Development• Folate (vitamin B9) is critical for DNA synthesis, repair, and methylation, which are essential processes during early brain development. Deficiencies in folate during pregnancy have been associated with neural tube defects and developmental delays, which can increase the risk of neurodevelopmental disorders like autism.

• Ensuring adequate folate levels during pregnancy may help support healthy brain development in the fetus, reducing the risk of developmental issues, including autism.

2. Folate Metabolism and MTHFR Gene

• Some individuals with autism may have genetic mutations, such as MTHFR polymorphisms, that impair their ability to convert folic acid into its active form, L-methylfolate. This can lead to folate deficiencies, which may exacerbate or contribute to symptoms of autism.

• Supplementing with L-methylfolate bypasses the need for conversion, ensuring that the body and brain have the necessary folate available for crucial functions like neurotransmitter production and DNA repair.

3. Cerebral Folate Deficiency (CFD) and Autism

• Cerebral folate deficiency (CFD) is a condition where folate levels are normal in the blood but low in the cerebrospinal fluid (CSF). This can lead to neurodevelopmental problems, and some research has shown a link between CFD and autism.

• Children with autism who have CFD may benefit from L-methylfolate supplementation, which can help increase folate levels in the brain and potentially improve symptoms such as communication, behavior, and cognitive function.

4. Autoimmune Folate Receptor Antibodies

• Some individuals with autism may have autoimmune antibodies that block folate receptors in the brain, preventing adequate folate transport into the brain. This is known as folate receptor autoimmunity, which has been found in some children with autism.

• Supplementation with high doses of folinic acid (a form of folate) has shown promise in these cases, improving symptoms such as language development and social communication. Studies have suggested that folinic acid may help bypass the blocked receptors and restore folate levels in the brain.

5. Folate and Neurotransmitter Production

• Folate is essential for the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine, which are often imbalanced in individuals with autism. Supporting adequate folate levels through L-methylfolate supplementation may help regulate these neurotransmitters, potentially improving mood, behavior, and cognitive function in individuals with autism.

6. Research on Folate and Autism

• Some studies have explored the role of folate supplementation in improving autism symptoms. For example, one study found that high-dose folinic acid improved communication skills in some children with autism, particularly those with folate receptor autoantibodies.

• Other studies have suggested that adequate maternal folate intake during pregnancy is associated with a reduced risk of autism in children. Prenatal folate supplementation is thought to be protective against developmental disorders, including autism, by supporting neural tube and brain development.

7. Potential Benefits of Folate Supplementation in Autism

• Improvement in communication and social skills: Some studies suggest that folinic acid or L-methylfolate supplementation may improve verbal communication, social interaction, and overall cognitive functioning in children with autism.

• Reduction in repetitive behaviors: By supporting neurotransmitter balance, folate may help reduce some of the repetitive or restrictive behaviors seen in individuals with autism.

• Support for brain function: Folate’s role in DNA methylation and neurotransmitter production may support brain function and development, leading to potential cognitive and behavioral improvements.

8. Considerations and Recommendations

• While folate supplementation, particularly in the form of L-methylfolate or folinic acid, shows promise for some individuals with autism, it is important to consult a healthcare professional before starting any supplementation. The type and dosage of folate should be tailored to the individual’s needs, especially if genetic factors like MTHFR mutations are present.

• Supplementation should be carefully monitored, particularly in children, as too much folate or inappropriate forms (e.g., synthetic folic acid in those with MTHFR mutations) could have unintended effects.

Conclusion

Folate, especially in the form of L-methylfolate or folinic acid, may offer benefits for individuals with autism by supporting neurotransmitter production, brain development, and improving symptoms like communication and social interaction. Its role in addressing issues such as cerebral folate deficiency and folate receptor autoimmunity is particularly relevant for some children with autism.

Parkinson's Disease

Folate, also known as vitamin B9, plays a critical role in maintaining brain health, and research has explored its potential benefits for individuals with Parkinson’s disease. Here are the key points on how folate might be relevant for Parkinson’s:

1. Homocysteine Regulation

• Folate is essential for the breakdown of homocysteine, an amino acid that can accumulate in the blood and contribute to neurodegenerative processes if present in high levels. Elevated homocysteine levels have been linked to cognitive decline and motor symptoms in Parkinson’s patients.

• Parkinson’s patients, especially those taking levodopa (a common medication for Parkinson’s), often experience elevated homocysteine levels because levodopa metabolism increases homocysteine production. Adequate folate intake helps convert homocysteine into harmless substances, potentially reducing its negative effects on the brain.

2. Methylation and Neurotransmitter Synthesis

• Folate plays a key role in methylation, a process that regulates gene expression and the production of neurotransmitters such as dopamine, serotonin, and norepinephrine. Since Parkinson’s disease is characterized by a loss of dopamine-producing neurons, ensuring optimal folate levels may support overall neurotransmitter balance.

• Low folate levels can disrupt methylation, potentially worsening neurological function and contributing to cognitive impairment in Parkinson’s disease.

3. Folate and Cognitive Function

• Cognitive decline and dementia are common in the later stages of Parkinson’s disease. Folate deficiency has been linked to impaired cognitive function, and maintaining adequate folate levels may help preserve cognitive health in individuals with Parkinson’s.

• Some studies suggest that folate supplementation might help improve cognitive function in neurodegenerative diseases, though more research is needed to confirm its specific effects in Parkinson’s.

4. Folate and Levodopa Treatment

• Levodopa, the most commonly used medication for managing Parkinson’s symptoms, can deplete the body’s folate levels and increase homocysteine production, as mentioned earlier. Folate supplementation may counteract these effects by reducing homocysteine levels and potentially improving the tolerability and effectiveness of levodopa.

• Supplementing with folate, especially in the form of L-methylfolate, may help mitigate some of the side effects associated with long-term levodopa use, such as cognitive decline and cardiovascular risks linked to elevated homocysteine.

5. MTHFR Gene and Folate Metabolism

• Some individuals may have a genetic variation in the MTHFR gene, which affects their ability to convert folic acid (the synthetic form of folate) into its active form, L-methylfolate. This can result in lower levels of active folate in the brain and higher homocysteine levels, potentially worsening Parkinson’s symptoms or cognitive decline.

• For individuals with this genetic variation, supplementing with L-methylfolate (the bioactive form of folate) may bypass this metabolic issue and help maintain proper brain function and reduce homocysteine levels.

6. Potential Neuroprotective Effects

• Folate’s role in DNA synthesis, repair, and methylation may have neuroprotective effects. By supporting these processes, folate could help reduce oxidative stress and inflammation, both of which contribute to the progression of Parkinson’s disease.

• While research is ongoing, folate’s neuroprotective potential makes it a promising area for further exploration in Parkinson’s disease management.

7. Research and Clinical Evidence

• Some studies have indicated that maintaining adequate folate levels is associated with better outcomes in neurodegenerative diseases, including Parkinson’s. However, more specific research is needed to fully understand the impact of folate supplementation on the progression of Parkinson’s disease.

• Clinical trials investigating folate’s effects on cognitive decline in neurodegenerative conditions like Alzheimer’s may offer insights relevant to Parkinson’s, given the overlap in cognitive issues and neurodegenerative mechanisms.

8. Folate-Rich Diet

• Maintaining a diet rich in natural sources of folate, such as leafy greens, beans, peas, and liver, may help manage homocysteine levels and support overall brain health in Parkinson’s patients.

• If dietary intake is insufficient, or if genetic factors affect folate metabolism, supplementation with L-methylfolate or folinic acid may be beneficial.

Conclusion

Folate, particularly in its active form (L-methylfolate), may play a supportive role in managing Parkinson’s disease by regulating homocysteine levels, supporting cognitive function, and potentially offering neuroprotective effects. Folate is particularly important for patients taking levodopa, as this medication can lead to elevated homocysteine levels, which folate can help counteract.

Ingredients

 Each serving size (1 vegetarian capsule) contains: Folate (as Metafolin, L-5-MTHF) 1,667 mcg DFE (L-5-MTHF 1,000 mcg). Other ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water).

Difference: What makes us different isn’t just our process or what goes into our supplements what we leave out matters, too.

This product is FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors and sweeteners, coatings and shellacs, GMOs, unnecessary binders, fillers and preservatives.

Our Folate Has No:  Wheat, Soy, Dairy, Eggs, Artificial Colors & Sweeteners,Coatings & Shellacs, GMO

Unnecessary Binders, Fillers Preservatives, Magnesium Stearate

Gluten,Trans Fat & Hydrogenated Oils,Tree Nuts, Peanuts & Sesame

 Dosage

As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.

Legal Disclaimer

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Always consult your health care provider before taking any supplements. Pregnant or lactating women, people with existing medical conditions, or people taking medications should consult their health care provider/s before taking any dietary supplement. If you experience any adverse condition after taking this dietary supplement, discontinue use immediately and consult your health care provider. Keep out of reach of children